by Elisa Cascade and Amir H. Kalali, MD

Ms. Cascade is Vice President, Quintiles Inc./iGuard, Falls Church, Virginia; and Dr. Kalali is Vice President, Global Therapeutic Group Leader CNS, Quintiles Inc., San Diego, California, and Professor of Psychiatry, University of California, San Diego.

Read the rest of this article »

by Charles A. Morgan III, MD, MA; Gary Hazlett, PsyD; Mike Dial-Ward, PhD;
Steven M. Southwick, MD

Drs. Morgan and Southwick are from the Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut; Dr. Hazlett is with Woodward-Cody Specialty Consultants, Inc. and was with US Army Special Warfare Training Center Psychologists, Fort Bragg, North Carolina at the time of this study; and Dr. Dial-Ward is with FASOTRAGRUPAC, US NAS, North Island, Coronado, California.

Read the rest of this article »

by Alvaro Camacho, MD; Bernardo Ng, MD; Barbara Galangue, MA; David Feifel, MD, PhD

Drs. Camacho and Ng are with the Imperial County Behavioral Health, El Centro, California, the Sun Valley Research Center, Imperial, California, and the Department of Psychiatry. University of California, San Diego; Ms. Galangue and Dr. Feifel are with the Department of Psychiatry. University of California, San Diego.

Read the rest of this article »

by Richard H. Weisler, MD; Amir H. Kalali, MD; Andrew J. Cutler, MD; Thomas D. Gazda, MD; and Lawrence Ginsberg, MD
Dr. Weisler is from Duke University Medical Center, Durham, North Carolina, and University of North Carolina at Chapel Hill Departments of Psychiatry, Raleigh, North Carolina; Dr. Kalali is from Quintiles, Inc. and University of California, San Diego, California; Dr. Cutler is from Department of Psychiatry, University of Florida, Gainsville, and Florida Clinical Research Center, LLC, Maitland, Florida; Dr. Gazda is from Banner Behavioral Health Hospital, Scottsdale, Arizona; and Dr. Ginsberg is from Red Oak Psychiatry Associates, Houston, Texas.

Read the rest of this article »

by Andrew Donohue, DO; Vinay Arya, MD; Lawrence Fitch, JD; and Debra Hammen, LCSW-C

Dr. Donohue is from Forensic Psychiatrist, Delaware Psychiatric Center, New Castle, Deleware; Dr. Arya is Attending Psychiatrist, Monmouth Medical Center, Long Branch, New Jersey; Dr. Fitch is Maryland Director of Forensic Services, Jessup, Maryland; and Ms. Hammen is Chief, Systems Operation, Maryland Office of Forensic Services, Jessup, Maryland.

Read the rest of this article »

by Richard H. Weisler, MD; Amir H. Kalali, MD; Andrew J. Cutler, MD; Thomas D. Gazda, MD; and Lawrence Ginsberg, MD

Dr. Weisler is from Duke University Medical Center, Durham, North Carolina, and University of North Carolina at Chapel Hill Departments of Psychiatry, Raleigh, North Carolina; Dr. Kalali is from Quintiles, Inc. and University of California, San Diego, California; Dr. Cutler is from Department of Psychiatry, University of Florida; Florida Clinical Research Center, LLC, Maitland, Florida; Dr. Gazda is from Banner Behavioral Health Hospital, Scottsdale, Arizona; and Dr. Ginsberg is from Red Oak Psychiatry Associates, Houston, Texas.

Read the rest of this article »

by Imtiaz Ahmad Dogar, MBBS, FCPS; Imran S. Khawaja, MD; Muhammad Waqar Azeem, MD; Huma Awan, MSc; Afshan Ayub, MSc; Javed Iqbal, MBBS; and Paul Thuras, PhD

Dr. Dogar is from the Department of Psychiatry, DHQ Hospital, Punjab Medical College, Faisalabad, Pakistan; Dr. Khawaja is from the Department of Psychiatry, VA Medical Center, Minneapolis, Minnesota, and from the University of Minnesota School of Medicine, Minneapolis; Dr. Azeem is from the Riverview Hospital for Children and Youth, Middletown, Connecticut, Department of Children and Families, Connecticut, Yale Child Study Center, and Department of Psychiatry, University of Connecticut School of Medicine; Drs. Awan and Ayub are from the Department of Psychiatry, DHQ Hospital, Punjab Medical College, Faisalabad, Pakistan; Dr. Iqbal is from the Department of Cardiology, DHQ Hospital, Punjab Medical College, Faisalabad, Pakistan; and Dr. Thuras is from the Department of Psychiatry, VA Medical Center, Minneapolis, Minnesota.

Read the rest of this article »

by Leo Bastiaens, MD

Dr. Bastiaens is from Family Services of Western Pennsylvania and is Clinical Associate Professor of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania

Read the rest of this article »

by Joseph Peuskens, Jitendra Trivedi, Sergiy Malyarov, Martin Brecher, Ola Svensson, Frank Miller, Inger Persson, and Didier Meulien on behalf of the Study D1444C00004 investigators

Dr. Peuskens is with Universitair Psychiatrisch Centrum KU Leuven, Campus St Jozef Kortenberg, Belgium; Dr. Trivedi is with King George Medical University, Lucknow, India; Dr. Malyarov is with Kyiv Psychoneurological Hospital, Kyiv, Ukraine; Dr. Brecher is with AstraZeneca Pharmaceuticals, Wilmington, Delaware, US; and Drs. Svensson, Miller, Persson, and Meulien are with AstraZeneca Research and Development in Södertälje, Sweden.

Read the rest of this article »

by James Russell, MD; Joel Raskin, MD; Curtis Wiltse, PhD; Daniel Walker, PhD; and Olga Brawman-Mintzer, MD

Drs. Russell, Wiltse, and Walker are with Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana; Dr. Raskin is with Lilly Research Laboratories, Eli Lilly Canada, Toronto, Ontario, Canada; and Dr. Brawman-Mintzer is with the Medical University of South Carolina, Charleston, South Carolina.

Financial support: This work was sponsored by Eli Lilly and Company and Boehringer Ingelheim GmbH.

Clinical trial registry number for this study: NCT00062673 at www.clinicaltrials.gov. First patient enrolled in this study (assigned to therapy): 18 March 2003. Last patient completed: 22 July 2004.

Disclosures: Drs. Russell, Raskin, Wiltse, and Walker are employees of Eli Lilly and Company; Dr. Brawman-Mintzer is on the speakers bureau of AstraZeneca, Forest Pharmaceuticals, Pfizer Inc., Eli Lilly, and Janssen Pharmaceutica, has received grant/research support from Pfizer, Forest Pharmaceuticals, AstraZeneca, Janssen Pharmaceutica, Biovail, UCB Pharma, Eli Lilly, Novartiz, and Sanofi-Aventis, and is a consultant to Pfizer, UCB Pharma, Janssen Pharmaceutica, AstraZeneca, Solvay.

Key Words: duloxetine, anxiety, major depressive disorder, elderly, placebo

ABSTRACT

Objective: To compare the efficacy and tolerability of duloxetine 60mg/day versus placebo in treating elderly patients with major depressive disorder (MDD) and concurrent anxiety symptoms.

Read the rest of this article »